ncRNA name | rno-miR-195 |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Rattus norvegicus |
Tissues/Cell_line | retinas |
Methods | RT-PCR, transfection, luciferase reporter assay, in situ hybridisation, immunohistochemistry, Western blot |
Expression pattern | up-regulated |
Functional description | A luciferase assay confirmed the binding of miR-195 to the 3' untranslated region of SIRT1. miR-195 expression was upregulated in retinas of diabetic rats and intravitreal injection of miR-195 antagomir ameliorated levels of SIRT1. |
PubMed ID | 24570140 |
Year | 2014 |
Title | miR-195 regulates SIRT1-mediated changes in diabetic retinopathy. |
Drug-related ncRNA | NO |
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